Generally no — "vs" is lowercase in AP Style and Chicago Style as a preposition equivalent.
"Vs" or "vs." — short for "versus" — is generally treated as a preposition by style guides and lowercased in the middle of a title in AP Style and Chicago Style. In sports headlines and legal contexts, it may be capitalized or written as "v."
AP Style recommends the spelling "vs." with a period in general usage and "v." without a period in legal contexts. The capitalization rule is lowercase in both cases when used in the middle of a title.
In sports headlines and entertainment matchup contexts, "vs." sometimes appears in uppercase for dramatic effect — "Patriots vs. Eagles" or "Alien Vs. Predator." This is a stylistic choice rather than a strict rule, and it varies by publication.
When "vs" opens a title it is always capitalized, as with any first word. It rarely appears as the final word of a title.
"Vs" is an abbreviation of the Latin "versus" and functions like a preposition in English. AP Style and Chicago Style both lowercase prepositions in the middle of a title, and "vs" follows the same treatment.